Monitoring progress in reducing maternal mortality using verbal autopsy methods in vital registration systems: what can we conclude about specific causes of maternal death?

6 év ago
Reducing maternal mortality is a key focus of development strategies and one of the indicators used to measure progress towards achieving the Sustainable Development Goals. In the absence of medical certificat...
Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury and Alan D. Lopez

The DM-scope registry: a rare disease innovative framework bridging the gap between research and medical care

6 év ago
The relevance of registries as a key component for developing clinical research for rare diseases (RD) and improving patient care has been acknowledged by most stakeholders. As recent studies pointed to severa...
Marie De Antonio, Céline Dogan, Ferroudja Daidj, Bruno Eymard, Jack Puymirat, Jean Mathieu, Cynthia Gagnon, Sandrine Katsahian, Dalil Hamroun and Guillaume Bassez

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study

6 év ago
Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, ...
Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast and Andre…

Molecular investigation, using chromosomal microarray and whole exome sequencing, of six patients affected by Williams Beuren syndrome and Autism Spectrum Disorder

6 év ago
Williams Beuren syndrome (WBS) is a multiple malformations/intellectual disability (ID) syndrome caused by 7q11.23 microdeletion and clinically characterized by a typical neurocognitive profile including exces...
Julie Masson, Caroline Demily, Nicolas Chatron, Audrey Labalme, Pierre-Antoine Rollat-Farnier, Caroline Schluth-Bolard, Brigitte Gilbert-Dussardier, Fabienne Giuliano, Renaud Touraine, Sylvie Tordjman, Alain Verloes, Giuseppe Testa, Damien Sanlaville,…

Who says “no” to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program

6 év ago
Successful stroke trials require adequate recruitment. In this observational study, we assessed reasons for refusal to provide informed consent in eligible patients approached for clinical trial participation ...
Zoe R. O’Neill, Halina M. Deptuck, Lauren Quong, Genoveva Maclean, Karina Villaluna, Princess King-Azote, Mukul Sharma, Ken Butcher, Robert G. Hart and Thalia S. Field

Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind,…

6 év ago
Taurine (Tau) is involved in many biochemical functions such as regulation of glucose and lipid metabolism, enhancement of energy expenditure, anti-inflammatory effects and appetite control. The most important...
Fatemeh Haidari, Maryam Asadi, Javad mohammadi-asl and Kambiz Ahmadi-Angali

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model

6 év ago
Verbal autopsy is an increasingly important methodology for assigning causes to otherwise uncertified deaths, which amount to around 50% of global mortality and cause much uncertainty for health planning. The ...
Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler and Max Petzold

Current challenges in the management of patients with sickle cell disease – A report of the Italian experience

6 év ago
Sickle cell disease (SCD) is an inherited red blood cell disorder caused by a structural abnormality of hemoglobin called sickle hemoglobin (HbS). Clinical manifestations of SCD are mainly characterized by chr...
Giovanna Russo, Lucia De Franceschi, Raffaella Colombatti, Paolo Rigano, Silverio Perrotta, Vincenzo Voi, Giovanni Palazzi, Carmelo Fidone, Alessandra Quota, Giovanna Graziadei, Antonello Pietrangelo, Valeria Pinto, Giovan Battista Ruffo, Francesco…

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