Hepatitis B Viral Markers in the Human Milk of HBsAg-Positive Mothers: An Observational Study

3 év 9 hónap ago
Journal of Human Lactation, Ahead of Print.
Background:Quantification of viral antigens and viral loads in human milk samples from mothers infected with hepatitis B virus is largely unknown.Research Aim:The aim of the study was to quantitatively measure the levels of viral antigens and deoxyribonucleic acid of hepatitis B virus in human milk from mothers infected with hepatitis B virus.Methods:Fifty-five pairs of milk and serum samples from mothers with positive hepatitis B surface antigen, including 11 hepatitis B e antigen positive, were quantitatively tested to measure viral antigens by microparticle enzyme immunoassay and viral loads by real-time polymerase chain reaction assay.Results:The median level of hepatitis B surface antigen in the human milk samples of mothers with positive or negative hepatitis B e antigen was each lower than that in the sera, respectively (1.10 vs. 4.32 log10 IU/ml, t = 10.693, p < .001; -0.77 vs. 2.53 log10 IU/ml, t = -25.135, p < .001). The titers of hepatitis B surface antigen or hepatitis B e antigen in the human milk samples were each correlated with that in maternal serum. The detectable level of deoxyribonucleic acid of hepatitis B virus in human milk ranged from 1.42–5.27 log10 IU/ml, whereas that in maternal sera was 1.44–8.66 log10 IU/ml. The viral level in human milk was not correlated with that in maternal circulation.Conclusion:The present study data illustrate the relatively low titers of viral markers in the milk of mothers with positive hepatitis B surface antigen.
Hongyu Huang

Prelacteal feeding practice and its associated factors among mothers having children less than 2 years of age in East Africa: a multilevel analysis of the recent demographic and health surveys

3 év 9 hónap ago
Prelacteal feeding is a major public health problem that increases the risk of morbidity and mortality in children. It also result delayed breastfeeding initiation and interferes with exclusive breastfeeding. ...
Achamyeleh Birhanu Teshale, Misganaw Gebrie Worku, Zemenu Tadesse Tessema and Getayeneh Antehunegn Tesema

Initiation of Gender-Affirming Testosterone Therapy in a Lactating Transgender Man

3 év 9 hónap ago
Journal of Human Lactation, Ahead of Print.
Introduction:Transgender and gender diverse individuals may choose to provide their infants with human milk. Lactating transgender men may experience gender dysphoria and desire to initiate or reinitiate gender-affirming testosterone therapy. However, there is limited safety data regarding use of testosterone during lactation.Main Issue:A 30-year-old G2P2 transgender man with gender dysphoria sought to initiate gender-affirming testosterone therapy while lactating.Management:Subcutaneous testosterone was self-administered beginning at 13 months post-partum. We prospectively collected data on circulating testosterone concentrations in parent serum, milk, and infant serum over 5 months until the infant self-weaned. The infant was monitored for growth and development at routine pediatric outpatient appointments. Parent serum testosterone concentrations rose with the initiation of testosterone therapy, reaching therapeutic concentrations by Day 14. Milk testosterone concentrations also increased with a maximum concentration of 35.9 ng/dl when the lactating parent was on a dose of 80 mg subcutaneous testosterone cypionate weekly. The calculated milk/plasma ratio remained under 1.0 and the calculated relative infant dose remained under 1%. The infant had no observable side effects, and his serum testosterone concentrations remained undetectable throughout the study period.Conclusion:This is the first study with data regarding human milk and infant serum testosterone concentrations during the initiation of gender-affirming testosterone therapy in a lactating individual. This evidence can help families and clinicians with decisions regarding lactation and testosterone use.
Sara Oberhelman-Eaton

When Is Pumping Too Much, Not Enough, or Just Right?

3 év 9 hónap ago

I’m often asked the question: “Do nursing parents need to pump in order to make enough milk?” The short answer is no. Effective breast pumps have been available for only about the past 70 years. Clearly humans have successfully nursed their babies for far longer. Also, how many of the thousands of other mammal species need to pump to produce adequate milk? None, of course.  

But in some cases, pumping—and/or hand expressing milk—is crucial to meeting lactation goals. The key is understanding when pumping makes sense and how often and how much milk to pump. Too much pumping can lead to painful oversupply. Too little pumping sometimes leads to low milk production, especially when baby nurses ineffectively or the nursing couple is regularly separated at feeding times. Let’s consider this issue from the Goldilocks perspective: When is pumping too much, not enough, or just right?

When Is Pumping Too Much?

Nursing parents anxious about milk production often err on the side of too much pumping. Recently, a mother of a 2-month-old baby asked me when she could comfortably sleep as long as her baby slept at night without needing to pump to relieve her breast discomfort. Her baby recently started sleeping for longer stretches, but uncomfortable breast fullness prevented her from doing the same, not to mention she suffered from recurring plugged ducts.

As we talked, she revealed that soon after her baby’s birth, she began using her all-silicone Haakaa pump at every nursing session—day and night—to collect milk from one side while her baby nursed on the other side (see photo below). At the time, she was collecting 3 or 4 extra ounces (90-120 mL) of milk at each nursing session around the clock, and her freezer was full to bursting. Now I understood why her body would not let her sleep when her baby slept.

I explained that at birth, her body knew how much milk to make based on the number of effective daily milk removals. Although she gave birth to one baby, because she was expressing so much milk so often, her body thought she had delivered twins and was making twice as much milk as her baby consumed.

Before she could be comfortable sleeping for longer stretches, she needed to gradually reduce her pumping until she reached the right level of milk production for one baby, not two. To do this, I suggested she eliminate one daily Haakaa session every 3 to 4 days to give her body a chance to reduce milk production gradually and comfortably. Within 2 weeks or so, she could sleep for longer stretches at night without needing to pump, and her recurring plugged ducts were gone.

How much pumping is too much? On average, pumping once or twice a day is not enough to make a noticeable difference in milk production. But when a baby is nursing at least 8 times per day and a parent adds three, four, or more pump sessions each day, this can generate an oversupply, especially when pumping starts during the first 2 weeks after birth, a period when a birthing parent’s body responds most intensely to mammary stimulation.

Using an all-silicone haakaa pump while baby nurses

Some parents wonder if there can really be “too much of a good thing” when it comes to making milk. Definitely! Oversupply (aka hyperlactation or hypergalactia) is defined as making so much more milk than a normally-growing baby needs that the parent must express milk regularly just to stay comfortable. For this parent, oversupply often leads to painful fullness, recurring mastitis, profuse milk leakage, and painful nipples if baby clamps down during nursing to slow milk flow. For babies, very fast milk flow can make nursing challenging. They may gain weight at double or triple the expected range. Many also develop digestive issues (explosive green, frothy, or bloody stools) and colicky behavior.

A gradual reduction of excess pumping over time as described above can relieve these symptoms without triggering plugged ducts. For many families, slowing milk production to a more manageable level makes nursing a more positive experience for both parent and baby.

When Is Pumping Not Enough?

Are there times when more pumping is a good idea? Yes. When a baby is unable to nurse directly or effectively at feeds, pumping can substitute for baby in establishing or maintaining milk production. One example is the baby born so preterm that effective nursing is not possible for weeks or months. In this situation, intensive pumping is required to produce adequate milk, which can be stressful. When pumping substitutes entirely for a nursing baby, to reach full milk production (about 25 oz. or 750 mL of milk per day per baby), parents need to pump early (ideally within the first few hours after birth), often (at least 8 times per 24 hours during the first 2 weeks), and effectively. The hands-on pumping techniques described HERE increase pumping effectiveness by an average of about 50%.

More pumping may also be a good choice when the nursing couple is regularly separated at feeding times, such as when the parent returns to work or school. In this situation, pumping keeps the parent comfortable and prevents leaking milk while also providing the milk baby needs. For more details on how to meet nursing goals even with regular separation, see my book for employed nursing parents HERE.

For parents pumping long term, the key to keeping milk production stable is keeping the number of daily milk removals (nursing plus pumping sessions) at the right level over time. Parents’ “magic number” of milk removals (see my post on that HERE) varies based on the physical difference known as storage capacity. Knowing your magic number makes it easier to meet your long-term lactation goals. For a more in-depth explanation, see my journal article HERE.

When Is Pumping Just Right?

For families who plan to exclusively human-milk feed their baby for the first 6 months, expressing milk may play an important role. When away from their baby at feeding times for any reason, pumping keeps parents comfortable, their milk production steady, and provides milk for their baby. If a nursing problem such as latching struggles occurs, pumping can ensure ample milk until the problem is solved.

Teaching all birthing parents to hand express milk is part of the Baby-Friendly Hospital Initiative. By mastering this skill, new parents can relieve any mammary fullness when their sleeping baby cannot be roused to nurse. Expressing a little milk can more quickly reduce any engorgement and prevent plugged ducts. Pumping just “to comfort” (rather than fully draining the glands) as needed can make the early weeks after birth more pleasant as milk production adjusts to the baby’s needs.

On her website firstdroplets.com, U.S. pediatrician Dr. Jane Morton recommends all parents learn to hand express milk during the last month of a low-risk pregnancy. (A pregnancy is sufficiently low risk when sexual relations are not prohibited.) THIS 2017 Australian randomized controlled trial found this practice did not trigger early labor or any other pregnancy complications. Morton also suggests during the first 3 days after birth that parents follow nursing sessions by hand-expressing a little colostrum (the first milk) into a spoon and feed baby this “dessert.” Why? This simple act can prevent three common problems:

©2021 Dr. Jane Morton, used with permission

  • Excess infant weight loss

  • Exaggerated newborn jaundice

  • Delayed increase in milk production

 Studies also found that learning hand expression at the end of pregnancy can boost parents’ confidence in their ability to meet their feeding goals. Parents who learned to hand express before birth are less likely than others to use formula in the hospital (study HERE) and are more confident in their ability to produce enough milk (study HERE). See Morton’s instructional videos for learning hand expression during pregnancy at firstdroplets.com.

In other words, even when nursing is going normally, a little pumping or hand expressing is sometimes exactly the right thing to do.

Making Decisions

When is pumping too much, not enough, or just right? This is not a black-and-white issue. Like Goldilocks’ choices, subjective factors play a role. When pondering the best course of action, nursing parents need to consider their situation, their long-term goals, their body’s response, and their individual and family needs. Over time, many of these variables are likely to change, so as with all aspects of parenting, flexibility and an open mind are tremendous assets.

Nancy Mohrbacher

A cross-sectional study of lactation room quality and Dutch working mothers’ satisfaction, perceived ease of, and perceived support for breast milk expression at work

3 év 9 hónap ago
The challenge of combining professional work and breastfeeding is a key reason why women choose not to breastfeed or to stop breastfeeding early. We posited that having access to a high-quality lactation room ...
Sjoukje A. van Dellen, Barbara Wisse, Mark P. Mobach, Casper J. Albers and Arie Dijkstra

One-week recall period gives a more accurate estimate of exclusive breastfeeding practice than 24-h recall among infants younger than six months of age

3 év 10 hónap ago
The World Health Organization recommends a 24-h recall period to estimate breastfeeding practice of mothers of infants aged younger than six-months. Though 24-h recall was preferred for its low recall bias and...
Sewitemariam Desalegn Andarge, Esete Habtemariam Fenta, Seifu Hagos Gebreyesus and Robel Yirgu Belachew

Good practices in perinatal care and breastfeeding protection during the first wave of the COVID-19 pandemic: a national situation analysis among BFHI maternity hospitals in Spain

3 év 10 hónap ago
Although the positive effects of good clinical quality standards in perinatal care and breastfeeding support for women, newborns and families have been already demonstrated, many of these practices were disrup...
Barbara Muñoz-Amat, Carmen Rosa Pallás-Alonso and María-Teresa Hernández-Aguilar

New Tools for Implementing Lactation Counselling Programs

3 év 10 hónap ago
“Skilled breastfeeding counselling meant that breastfeeding could remain a choice for me and my baby.”  “Having skilled breastfeeding counselling completely changed my mental state. It was transformative.” “Without it, I probably would have just given up and never breastfed ever again.” These are direct quotes from parents, shared in a new video released during the […]
lactationmatters

Administration of breast milk cell fractions to neonates with birthweight equal to or less than 1800 g: a randomized controlled trial

3 év 10 hónap ago
Most premature and very low birthweight infants cannot tolerate breast milk feeding in the first few days of life and are deprived of its benefits. This study evaluates the clinical outcomes of administering b...
Minoo Fallahi, Seyed Masoud Shafiei, Naeeme Taslimi Taleghani, Maryam Khoshnood Shariati, Shamsollah Noripour, Fatemeh Pajouhandeh, Sina Kazemian, Mahmood Hajipour and Mohammad Kazemian

Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial

3 év 10 hónap ago
Oropharyngeal administration of colostrum (OAC) may provide immunoprotective and anti-inflammatory effects that potentially reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis and imp...
Xia OuYang, Chang-Yi Yang, Wen-Long Xiu, Yan-Hua Hu, Su-Su Mei and Qin Lin