Human Colostrum and Derived Extracellular Vesicles Prevent Infection by Human Rotavirus and Respiratory Syncytial Virus in Vitro

4 év 4 hónap ago
Journal of Human Lactation, Ahead of Print.
BackgroundIt is known that breastfeeding protects the infant from enteric and respiratory infections; however, the antiviral properties of human milk against enteric and respiratory viruses are largely unexplored.Research aimsTo explore the antiviral activity of human preterm colostrum against rotavirus and respiratory syncytial virus and to assess whether the derived extracellular vesicle contribute to this activity.MethodsWe used a cross-sectional, prospective two-group non-experimental design. Colostra were collected from mothers of preterm newborns (N = 10) and extracellular vesicles were purified and characterized. The antiviral activity of colostra and derived extracellular vesicles were tested in vitro against rotavirus and respiratory syncytial virus and the step of viral replication inhibited by extracellular vesicles was investigated.ResultsEach sample of colostrum and colostrum-derived extracellular vesicles had significant antiviral activity with a wide interpersonal variability. Mechanism of action studies demonstrated that extracellular vesicles acted by interfering with the early steps of the viral replicative cycle.ConclusionWe demonstrated the intrinsic antiviral activity of human colostrum against rotavirus and respiratory syncytial virus and we showed that extracellular vesicles substantially contribute to the overall protective effect. Our results contribute to unravelling novel mechanisms underlying the functional role of human milk as a protective and therapeutic agent in preterm infants.
Andrea Civra

An Interview With Patti Rundall: A Passionate Activist, Full of Energy!

4 év 4 hónap ago
Journal of Human Lactation, Ahead of Print.
Since 1980, alongside IBFAN partners, Patti Rundall has worked to build collaborative networks that help countries bring in legally binding controls based on the International Code of Marketing of Breastmilk Substitutes and the United Nations World Health Assembly (WHA) Resolutions. Conflicts of interest and their impact on policymaking, research, education, and health systems has been a cross-cutting theme of her work, which has focused on the adoption and strengthening of the European Union’s baby food legislation and the improvement of Codex Global Trading Standards. With IBFAN, she helped countries adop many resolutions including WHA Resolution 49.15 https://www.who.int/nutrition/topics/WHA49.15_iycn_en.pdf?ua=1 (1996) about conflicts of interest; she helped found and launch the Conflicts of Interest Coalition at the UN General Assembly. Patti is a founder of Baby Feeding Law Group (the alliance of 23 United Kingdom health professional and mother-support organizations), a member of the Infant Feeding in Emergencies core group and a leader in company campaigns (e.g., the Nestlé Boycott). She represented IBFAN on the European Commission’s Platform for Action on Diet and Physical Activity from 2007 until 2019. In the year 2000 she was awarded the title Officer of the British Empire (OBE) for her service to infant nutrition. (This is a verbatim interview: MA = Maryse Arendt; PR = Patti Rundall.)
Patti Rundall

Determinants of optimum exclusive breastfeeding duration in rural India: a mixed method approach using cohort and content analysis design

4 év 5 hónap ago
Despite established benefits, exclusive breastfeeding (EBF) rate remains poor in India. This study measured the rate of early initiation of breastfeeding and EBF up to 42 days postpartum period and the reasons...
Falguni Debnath, Nilanjan Mondal, Alok Kumar Deb, Debjit Chakraborty, Subhrangshu Chakraborty and Shanta Dutta

Vulnerable families and costly formula: a qualitative exploration of infant formula purchasing among peri-urban Peruvian households

4 év 5 hónap ago
Substantial evidence exists surrounding the health risks of breast milk substitutes (BMS) in place of exclusive breastfeeding among infants < 6 months of age in resource-poor settings. Yet, mothers’ experience...
Jessica D. Rothstein, Peter J. Winch, Jessica Pachas, Lilia Z. Cabrera, Mayra Ochoa, Robert H. Gilman and Laura E. Caulfield

Determinants of low breastfeeding self-efficacy amongst mothers of children aged less than six months: results from the BADUTA study in East Java, Indonesia

4 év 5 hónap ago
Despite the increasing rate of exclusive breastfeeding in Indonesia, there is still a need for supportive interventions. The breastfeeding self-efficacy of mothers is a key factor positively associated with op...
Christiana Rialine Titaley, Michael J. Dibley, Iwan Ariawan, Anifatun Mu’asyaroh, Ashraful Alam, Rita Damayanti, Tran Thanh Do, Elaine Ferguson, Kyaw Htet, Mu Li, Aang Sutrisna and Umi Fahmida

Sore Nipple Infographic Debuts

4 év 5 hónap ago

Today’s busy families want lactation information that is quick, easy, and lovely to the eye. That’s why I joined forces with the talented people at Noodle Soup to create for those in the U.S. a series of infographics on some of the most in-demand lactation topics.

 I’m thrilled to announce a new addition to this series! The #2 reason new parents give formula and wean prematurely is nipple pain. This new infographic—“Sore Nipple Basics”—directly addresses this problem and offers guidance on ways to achieve comfortable nursing. My hope is that it will help more families meet their feeding goals.  

All five of my infographics come in tearpads of 50 with one side in English and the other side in Spanish. You can find all five on one page HERE, or you can click on the titles below to link to their order pages on the Noodle Soup website.  

Sore Nipple Basics Includes positioning and latching strategies that can reduce pain, as well as other possible causes of nipple pain and who to contact for help.

Is Baby Getting Enough Milk?  Includes reliable signs that baby’s milk intake is adequate, expected feeding patterns in nursing newborns, and the most common false alarms. 

Working & Breastfeeding  The most important aspects of working and breastfeeding that nursing families need to know to meet their long-term feeding goals.

Pumping Primer  A simple guide to expressing milk that includes the key points needed for successful pumping.

For Baby’s Caregiver  Ways caregivers can support nursing families, including how to pace bottle feeds to avoid overfeeding during the workday.

Nancy Mohrbacher

Comparing breastfeeding experiences between mothers spending the traditional Chinese confinement period in a confinement centre and those staying at home: a cohort study

4 év 5 hónap ago
Ethnic Chinese mothers in Malaysia adhere to 30 days of traditional postpartum practices (the “confinement period”) aimed at recuperation after delivery. Recently there has been an emergence of confinement cen...
Siew Cheng Foong, May Loong Tan, Wai Cheng Foong, Jacqueline J. Ho and Fairuz Fadzilah Rahim

Predicting risk of early discontinuation of exclusive breastfeeding at a Brazilian referral hospital for high-risk neonates and infants: a decision-tree analysis

4 év 5 hónap ago
Determinants at several levels may affect breastfeeding practices. Besides the known historical, socio-economic, cultural, and individual factors, other components also pose major challenges to breastfeeding. ...
Maíra Domingues Bernardes Silva, Raquel de Vasconcellos Carvalhaes de Oliveira, Davi da Silveira Barroso Alves and Enirtes Caetano Prates Melo